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Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation.

TOGETHER WITH : Chemiosmotic Coupling and Energy Transduction.

pp. (ii), 192. 19 figures; vi, 111, (i). 8 figures. Both in cloth-backed grey paper wrappers, printed by off-set lithography from typescript, the 1968 paper inscribed by Mitchell - 'To Bill with warmest regards Peter July 1968', this also has a marginal correction, Bill or Mitchell ?, the 1966 paper has a few marginal pencil annotations, possibly by Bill, the corners of the front cover of the 1966 paper are very faintly creased and the cover itself has a couple of very faint brown spots, overall both copies in excellent condition.

*In 1978, PETER MITCHELL [1920-1992] was awarded the Nobel Prize for Chemistry; he was the sole recipient for that year. These two titles, self-published at his private research foundation, Glynn Research Laboratories, Bodmin, Cornwall, were affectionately known as 'The Little Grey Books of Chairman M.' Mitchell revolutionized our understanding of cellular metabolism and bioenergetics. See ANTONY CROFTS - Obituary in 'Photosynthesis Research' 1992: 'Peter Mitchell's 1961 paper introducing the chemiosmotic hypothesis started a revolution which has echoed beyond bioenergetics to all biology, and shaped our understanding of the fundamental mechanisms of biological energy conservation, ion and metabolite transport, bacterial motility, organelle structure and biosynthesis, membrane structure and function, homeostasis, the evolution of the eukaryote cell, and indeed every aspect of life in which these processes play a role. The Nobel Prize for Chemistry in 1978, awarded to Peter Mitchell as the sole recipient, recognized his predominant contribution towards establishing the validity of the chemiosmotic hypothesis, and ipso facto, the long struggle to convince an initially hostile establishment.' A comprehensive account of Mitchell and the Glynn Research Laboratories was given by JOHN PREBBLE and BRUCE WEBER in their biography of 2003 - Wandering in the Gardens of the Mind. Published by OUP New York, it was out of print by 2007 and is now very hard to find. NOBELPRIZE.ORG : All life requires energy. In both plants and animals, energy is stored and transported by the adenosine triphosphate (ATP) molecule. When an ATP molecule emits a phosphate group and forms ADP (adenosine diphosphate), energy is released. Details about how ATP is built up and broken down were unclear when Peter Mitchell presented his theory in 1961. It states that the basis for the process is a flow of electrons and hydrogen ions through membranes in the mitochondria of cells because of differences in electrical potential. The process is governed by indirect interaction between enzymes. SEE also : 'Beside his interest in communication between molecules, Peter Mitchell has become more and more interested in the problems of communication between individual people in civilised societies, especially in the context of the spread of violence in the increasingly collectivist societies in most parts of the world. His own experience of small and large organisations in the scientific world has led him to regard the small organisations as being, not only more alive and congenial, but also more effective, for many (although perhaps not all) purposes. He would therefore like to have the opportunity to become more deeply involved in studies of the ways in which sympathetic communication and cooperative activity between free and potentially independent people may be improved. One of his specific interests in this field of knowledge is the use of money as an instrument of personal responsibility and of choice in free societies, and the flagrant abuse and basically dishonest manipulation of the system of monetary units of value practised by the governments of most nations.' No longer housed at Glynn House, the Glynn Laboratory of Bioenergetics is today incorporated at UCL where it has its principal research interest in the use of vibrational infrared spectroscopy to address biophysical and biochemical questions. The two main areas of research are electron/proton transfer of respiratory chain enzymes and clinical diagnostics. In the light of Mitchell's late developed interest in human communications and cooperative activity, it is entirely fitting that the Glynn Laboratory has this specific statement : UCL Slavery and Human Trafficking Statement - This statement is made pursuant to Section 54 part 6 of the Modern Slavery Act 2015 and sets out the steps that UCL (University College London) has taken to ensure that slavery and human trafficking are not taking place in our supply chains or in any part of our business. Our policy on slavery and human trafficking - UCL is committed to acquiring goods and services for its use without causing harm to others.  In doing so, UCL is committed to supporting the UK Government's approach to implementing the UN Guiding Principles on Business and Human Rights. In implementing this approach UCL supports the Base Code of the Ethical Trading Initiative.

Glynn Research Ltd. [Bodmin, Cornwall].

Date Published: 1966; 1968. 2 volumes. Small 4to.

Stock No. 61899

Price: 3,000.00